Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit
Identifieur interne : 000085 ( Main/Exploration ); précédent : 000084; suivant : 000086Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit
Auteurs : Meghan O. Altman [États-Unis] ; Matthew Angel [États-Unis] ; Ivan Košík [États-Unis] ; Nídia S. Trovão [États-Unis] ; Seth J. Zost [États-Unis] ; James S. Gibbs [États-Unis] ; Lorenzo Casalino [États-Unis] ; Rommie E. Amaro [États-Unis] ; Scott E. Hensley [États-Unis] ; Martha I. Nelson [États-Unis] ; Jonathan W. Yewdell [États-Unis]Source :
- mBio [ 2150-7511 ] ; 2019.
Abstract
Frequent mutation of its major antibody target, the glycoprotein hemagglutinin, ensures that the influenza virus is perennially both a rapidly emerging virus and a major threat to public health. One type of mutation escapes immunity by adding a glycan onto an area of hemagglutinin that many antibodies recognize. This study revealed that these glycan changes follow a simple temporal pattern. Every 5 to 7 years, hemagglutinin adds a new glycan, up to a limit. After this limit is reached, no net additions of glycans occur. Instead, glycans are swapped or lost at longer intervals. Eventually, a pandemic replaces the terminally glycosylated hemagglutinin with a minimally glycosylated one from the animal reservoir, restarting the cycle. This pattern suggests the following: (i) some hemagglutinins are evolved for this decades-long process, which is both defined by and limited by successive glycan addition; and (ii) hemagglutinin's antibody dominance and its capacity for mutations are highly adapted features that allow influenza to outpace our antibody-based immunity.
Url:
DOI: 10.1128/mBio.00204-19
PubMed: 30940704
PubMed Central: 6445938
Affiliations:
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Altman</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Cellular Biology Section, Laboratory of Viral Diseases NIAID, NIH, Bethesda, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cellular Biology Section, Laboratory of Viral Diseases NIAID, NIH, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Angel, Matthew" sort="Angel, Matthew" uniqKey="Angel M" first="Matthew" last="Angel">Matthew Angel</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Cellular Biology Section, Laboratory of Viral Diseases NIAID, NIH, Bethesda, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cellular Biology Section, Laboratory of Viral Diseases NIAID, NIH, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kosik, Ivan" sort="Kosik, Ivan" uniqKey="Kosik I" first="Ivan" last="Košík">Ivan Košík</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Cellular Biology Section, Laboratory of Viral Diseases NIAID, NIH, Bethesda, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cellular Biology Section, Laboratory of Viral Diseases NIAID, NIH, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Trovao, Nidia S" sort="Trovao, Nidia S" uniqKey="Trovao N" first="Nídia S." last="Trovão">Nídia S. Trovão</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Division of International Epidemiology and Population Studies, Fogarty International Center, NIH, Bethesda, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of International Epidemiology and Population Studies, Fogarty International Center, NIH, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York City, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York City, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zost, Seth J" sort="Zost, Seth J" uniqKey="Zost S" first="Seth J." last="Zost">Seth J. Zost</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Gibbs, James S" sort="Gibbs, James S" uniqKey="Gibbs J" first="James S." last="Gibbs">James S. 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Amaro</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Chemistry and Biochemistry and the National Biomedical Computation Resource, University of California, San Diego, La Jolla, California, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry and Biochemistry and the National Biomedical Computation Resource, University of California, San Diego, La Jolla, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hensley, Scott E" sort="Hensley, Scott E" uniqKey="Hensley S" first="Scott E." last="Hensley">Scott E. Hensley</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I." last="Nelson">Martha I. Nelson</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Division of International Epidemiology and Population Studies, Fogarty International Center, NIH, Bethesda, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of International Epidemiology and Population Studies, Fogarty International Center, NIH, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Yewdell, Jonathan W" sort="Yewdell, Jonathan W" uniqKey="Yewdell J" first="Jonathan W." last="Yewdell">Jonathan W. Yewdell</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Cellular Biology Section, Laboratory of Viral Diseases NIAID, NIH, Bethesda, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cellular Biology Section, Laboratory of Viral Diseases NIAID, NIH, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Frequent mutation of its major antibody target, the glycoprotein hemagglutinin, ensures that the influenza virus is perennially both a rapidly emerging virus and a major threat to public health. One type of mutation escapes immunity by adding a glycan onto an area of hemagglutinin that many antibodies recognize. This study revealed that these glycan changes follow a simple temporal pattern. Every 5 to 7 years, hemagglutinin adds a new glycan, up to a limit. After this limit is reached, no net additions of glycans occur. Instead, glycans are swapped or lost at longer intervals. Eventually, a pandemic replaces the terminally glycosylated hemagglutinin with a minimally glycosylated one from the animal reservoir, restarting the cycle. This pattern suggests the following: (i) some hemagglutinins are evolved for this decades-long process, which is both defined by and limited by successive glycan addition; and (ii) hemagglutinin's antibody dominance and its capacity for mutations are highly adapted features that allow influenza to outpace our antibody-based immunity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Couch, Rb" uniqKey="Couch R">RB Couch</name></author><author><name sortKey="Kasel, Ja" uniqKey="Kasel J">JA Kasel</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Keil, W" uniqKey="Keil W">W Keil</name></author><author><name sortKey="Geyer, R" uniqKey="Geyer R">R Geyer</name></author><author><name sortKey="Dabrowski, J" uniqKey="Dabrowski J">J Dabrowski</name></author><author><name sortKey="Dabrowski, U" uniqKey="Dabrowski U">U Dabrowski</name></author><author><name 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sortKey="Altman, Meghan O" sort="Altman, Meghan O" uniqKey="Altman M" first="Meghan O." last="Altman">Meghan O. Altman</name></region><name sortKey="Amaro, Rommie E" sort="Amaro, Rommie E" uniqKey="Amaro R" first="Rommie E." last="Amaro">Rommie E. Amaro</name><name sortKey="Angel, Matthew" sort="Angel, Matthew" uniqKey="Angel M" first="Matthew" last="Angel">Matthew Angel</name><name sortKey="Casalino, Lorenzo" sort="Casalino, Lorenzo" uniqKey="Casalino L" first="Lorenzo" last="Casalino">Lorenzo Casalino</name><name sortKey="Gibbs, James S" sort="Gibbs, James S" uniqKey="Gibbs J" first="James S." last="Gibbs">James S. Gibbs</name><name sortKey="Hensley, Scott E" sort="Hensley, Scott E" uniqKey="Hensley S" first="Scott E." last="Hensley">Scott E. Hensley</name><name sortKey="Kosik, Ivan" sort="Kosik, Ivan" uniqKey="Kosik I" first="Ivan" last="Košík">Ivan Košík</name><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I." last="Nelson">Martha I. Nelson</name><name sortKey="Trovao, Nidia S" sort="Trovao, Nidia S" uniqKey="Trovao N" first="Nídia S." last="Trovão">Nídia S. Trovão</name><name sortKey="Trovao, Nidia S" sort="Trovao, Nidia S" uniqKey="Trovao N" first="Nídia S." last="Trovão">Nídia S. Trovão</name><name sortKey="Yewdell, Jonathan W" sort="Yewdell, Jonathan W" uniqKey="Yewdell J" first="Jonathan W." last="Yewdell">Jonathan W. Yewdell</name><name sortKey="Zost, Seth J" sort="Zost, Seth J" uniqKey="Zost S" first="Seth J." last="Zost">Seth J. Zost</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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